Every December, the staff of Science singles out a significant development or achievement as the Breakthrough of the Year. This year, visitors to Science's website could pick their own favorite from the short list of candidates. Below are descriptions of Science's Breakthrough—the powerful genome-editing technique known as CRISPR—along with nine Runners-up and the results of the "People's Choice" poll. Rounding out the package are a few "Areas to Watch" likely to make news in the 2016; a retrospective Scorecard of last year's prognostications; and a look back at Breakdowns that set back or tarnished the scientific enterprise in 2015 (Source: Science).

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